> Corry Group
Demo2 first
Can we make selective sodium channel inhibitors to treat pain?
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What is the potential of nanotube desalination?
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How do anaesthetics find their target?
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Synthetic pores for separating sodium and potassium
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A new way to measure FRET
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Which advanced sampling method is best?
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How you set the temperature matters!
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Mapping the movement of guest molecules in porous crystals
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How do sodium channels select for sodium?

Our research examines the structure and function of a family of pore forming proteins known as biological ion channels. We aim to understand the mechanisms by which these proteins can identify and transport molecules across the cell membrane, and how the pores open and close to control this transport. In addition we are interested in studying transport in other kinds of pores, be they proteins, crystaline materials or synthetic membranes. Gaining a fundamental understanding of the operation of biological pores has allowed us to design synthetic porous membranes for industrial applications.

Proteins and macromolecules can be difficult to study due to their size, functioning at the interface of microscopic molecular behaviour and macroscopic mechanical behaviour. To investigate them we use a combination of computational techniques including ab initio, molecular dynamics, coarse grain, Brownian dynamics and macroscopic calculations. In addition we utilise FRET microscopy (Förster Resonance Energy Transfer) to experimentally study the conformational changes of proteins as they function.

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