Mechanisms of ion selectivity
Many biological molecules, including channels,
transporters, enzymes, macrocycles and DNA
selectively bind or transport ions. Although ion
selectivity is critical to the function of most
molecules, the physical mechanisms by which
it arises are not well understood. While we are
particularly interested in understanding the
origins of ion selectivity in biological channels,
many of the principles involved in these proteins
apply in other cases as well. By comparing the
results of detailed simulations on a range of
systems and developing model systems in which
different mechanisms can be teased out we are not
only explaining selectivity in each particular
case, but also slowly gaining an appreciation of
the many ways selective binding can arise and the
conditions in which each is important. Although
fundamental in nature, this research helps to
explain the functioning of a number of critical
molecules in human biology and lays the foundation
for future innovation in biomedical research.
Collaborators: Dylan Jayatilaka,
UWA
; Juanjo Nogueira,
Autonomous University of Madrid
Key publications:
J J Nogueira, B Corry. Ion
channel permeation and selectivity. In
Oxford handbook of neuronal ion channels A
Bhattacharjee (ed) Oxford Uni Press 2019.
Online manuscript
Mechanism of ion permeation and selectivity in a
voltage gated sodium channel.
J Am Chem
Soc, 134: 1840-1846, 2012.
Online manuscript
Mapping the Importance of Four Factors in
Creating Monovalent Ion Selectivity in
Biological Molecules.
Biophys. J. 100:
60-69, 2011.
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The predominant role of coordination number in potassium channel selectivity.
Biophys. J. 93:2635-2643, 2007.
pdf
Mechanisms of valence selectivity in biological ion channels.
Cellular and Molecular Life Sciences. 63: 301-315, 2006.
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B Corry, TW Allen, S Kuyucak, SH Chung. Mechanisms of Permeation and Selectivity in Calcium Channels.
Biophys. J. 80, 195-214, 2001.
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